Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst.
نویسندگان
چکیده
An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.
منابع مشابه
Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 1 شماره
صفحات -
تاریخ انتشار 2012